Hepatitis C Infections among Individuals who Received Transfusions prior to 1994 in Antioquia, Colombia
DOI:
https://doi.org/10.22516/25007440.435Keywords:
Hepatitis virus C, ELISA, genotype, transfusion of blood componentsAbstract
Introduction: Infection with the hepatitis C virus is a public health problem. According to the World Health Organization there are an estimated 184 million cases of HCV infection around the world. The main risk factor in developing countries is transfusion of blood components. In 1993, Colombian regulations began requiring serological screening by blood banks for infectious agents including HCV. Nevertheless, data about HCV infections in the population transfused before this date is limited.
Objective: The objective of this study is to describe the frequency of HCV infection in the population of individuals transfused before 1994 in Antioquia.
Materials and Methods: A total of 166 individuals transfused before 1994 agreed to participate in the study. ELISA tests for antibodies to HCV were performed on these patients’ serum samples. Samples that were positive were tested for the presence of the viral genome by RT-PCR of non-coding region 5.
Results and Conclusions: The frequency of anti-HCV antibodies in study population was 6.6% (11/166) while the HCV genome was present in seven of these eleven individuals. Genotype 1 was identified in four of the samples. No associations of different risk factors for transfusion in individuals with markers of HCV infection were found. This study provides data on the epidemiology of HCV infection in Colombia.
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