Neuroendocrine Tumor Polypoid Presentation: Case Report and Literature Review

Authors

DOI:

https://doi.org/10.22516/25007440.813

Keywords:

Neuroendocrine tumor, Rectal neoplasm, Polyp

Abstract

Diagnosis of rectal neuroendocrine tumor (NET) has increased due to the implementation of colonoscopies as a screening method. Most rectal NETs are less than 1cm at diagnosis time, confined to the submucosa, and well differentiated. They generally have a benign course and are treated mainly using endoscopic methods. Metastases are rare and depend on tumor size and other factors such as submucosal invasion, lymphatic spread, and histologic classification, which will determine the prognosis and treatment. We present a case of a rectal neuroendocrine tumor as a polyp during routine endoscopic screening and a review of the current literature.

Downloads

Download data is not yet available.

Author Biographies

Sergio Andrés Romero Serrano, Universidad Industrial de Santander

Residente de cirugía general, Universidad industrial de Santander. Bucaramanga, Colombia.

Edwin Alirio Baez Ariza, Hospital Universitario de Santander

Cirujano coloproctólogo, Universidad Industrial de Santander, Universidad Militar Nueva Granada, Clínica Foscal, Hospital Universitario de Santander. Bucaramanga, Colombia.

Sheyla Yurian Pardo Gonzalez, Clínica Foscal Internacional

Residente de cirugía general, Universidad Industrial de Santander. Médico general en la Clínica Foscal Internacional. Bucaramanga, Colombia.

Sebastián Martínez Martínez , Universidad Industrial de Santander

Residente de patología, Universidad Industrial de Santander. Bucaramanga, Colombia.

References

Bolsolino A. Tumores neuroendocrinos de colon y recto. Acta Gastroenterol Latinoam. 2018;48(4):328-338.

Ahmed M. Gastrointestinal neuroendocrine tumors in 2020. World J Gastrointest Oncol. 2020;12(8):791-807. https://doi.org/10.4251/wjgo.v12.i8.791

Lubarsch O. Uber den primaren Krebs des Ileum nebst Bemerkungen uber das gleichzeitige Vorkommen von Krebs und Tuberkulose. Virchows Arch. 1888;3:280-317. https://doi.org/10.1007/BF01966242

Oberndorfer S. Karzinoid Tumore des Dunndarms. Frankf Z Pathol. 1907;1:426-30.

Hrabe J. Neuroendocrine Tumors of the Appendix, Colon, and Rectum. Surg Oncol Clin N Am. 2020;29(2):267-279. https://doi.org/10.1016/j.soc.2019.11.010

André TR, Brito M, Freire JG, Moreira A. Rectal and anal canal neuroendocrine tumours. J Gastrointest Oncol. 2018;9(2):354-357. https://doi.org/10.21037/jgo.2017.10.01

Partelli S, Maurizi A, Tamburrino D, Baldoni A, Polenta V, Crippa S, et al. GEP-NETS update: a review on surgery of gastro-entero-pancreatic neuroendocrine tumors. Eur J Endocrinol. 2014;171(4):R153-62. https://doi.org/10.1530/EJE-14-0173

Jann H, Roll S, Couvelard A, Hentic O, Pavel M, Müller-Nordhorn J, et al. Neuroendocrine tumors of midgut and hindgut origin: tumor-node-metastasis classification determines clinical outcome. Cancer. 2011;117(15):3332-41. https://doi.org/10.1002/cncr.25855

Tichansky DS, Cagir B, Borrazzo E. Risk of second cancer in patients with colorectal carcinoids. Dis Colon Rectum 2002;45(1):91-97. https://doi.org/10.1007/s10350-004-6119-y

Caplin M, Sundin A, Nillson O, Baum RP, Klose KJ, Kelestimur F, et al. Barcelona Consensus Conference participants. ENETS Consensus Guidelines for the management with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms. Neuroendocrinology 2012;95(2):88-97. https://doi.org/10.1159/000335594

Starzyńska T, Deptała A, Królicki L, Kunikowska J, Londzin-Olesik M, Nasierowska-Guttmejer A, et al. Colorectal neuroendocrine neoplasms - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol. 2013;64(6):494-504. https://doi.org/10.5603/EP.2013.0032

Ramage JK, De Herder WW, Delle Fave G, Ferolla P, Ferone D, Ito T, et al. ENETS Consensus Guidelines Update for Colorectal Neuroendocrine Neoplasms. Neuroendocrinology. 2016;103(2):139-43. https://doi.org/10.1159/000443166

Ramage JK, Ahmed A, Ardill J, Bax N, Breen DJ, Caplin ME, et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs). Gut. 2012;61(1):6-32. https://doi.org/10.1136/gutjnl-2011-300831

Gonzalez RS. Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms. Surg Pathol Clin. 2020;13(3):377-397. doi: 10.1016/j.path.2020.04.002

Kim JY, Hong SM, Ro JY. Recent updates on grading and classification of neuroendocrine tumors. Ann Diagn Pathol. 2017;29:11-16. https://doi.org/10.1016/j.anndiagpath.2017.04.005

Lloyd RV, Osamura RY, Kloppel G, Rosai J. WHO Classification of Tumors of Endocrine Organs. 5.a edición. WHO; 2019.

Basuroy R, O›Donnell CM, Srirajaskanthan R, Ramage JK. Ileocolonic neuroendocrine tumours identified in the English bowel cancer screening programme. Colorectal Dis. 2018;20(4):O85-O91. https://doi.org/10.1111/codi.14033

Shim KN, Yang SK, Myung SJ, Chang HS, Jung SA, Choe JW, et al. Atypical endoscopic features of rectal carcinoids. Endoscopy. 2004;36(4):313-316. https://doi.org/10.1055/s-2004-814202

Rakici H, Akdogan RA, Yurdakul C, Canturk N. A case of rectal neuroendocrine tumor presenting as polyp. Int J Surg Case Rep. 2015;8C:59-61. https://doi.org/10.1016/j.ijscr.2015.01.031

Bertani E, Ravizza D, Milione M, Massironi S, Grana CM, Zerini D, et al. Neuroendocrine neoplasms of rectum: A management update. Cancer Treat Rev. 2018;66:45-55. https://doi.org/10.1016/j.ctrv.2018.04.003

Basuroy R, Haji A, Ramage JK, Quaglia A, Srirajaskanthan R. Review article: the investigation and management of rectal neuroendocrine tumours. Aliment Pharmacol Ther. 2016;44(4):332-45. https://doi.org/10.1111/apt.13697

Chi Y, Du F, Zhao H, Wang JW, Cai JQ. Characteristics and long-term prognosis of patients with rectal neuroendocrine tumors. World J Gastroenterol. 2014;20(43):16252-16257. https://doi.org/10.3748/wjg.v20.i43.16252

Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, et al. One hundred years after «carcinoid»: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26(18):3063-72. https://doi.org/10.1200/JCO.2007.15.4377

Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, et al. Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States. JAMA Oncol. 2017;3(10):1335-1342. https://doi.org/10.1001/jamaoncol.2017.0589

Figura 1. Imagen tomada de la colonoscopia que muestra un pólipo neuroendocrino en el tercio superior del recto de 2 cm de diámetro.

Published

2022-09-16

How to Cite

Romero Serrano, S. A., Baez Ariza, E. A., Pardo Gonzalez, S. Y., & Martínez Martínez , S. (2022). Neuroendocrine Tumor Polypoid Presentation: Case Report and Literature Review. Revista Colombiana De Gastroenterología, 37(3), 325–329. https://doi.org/10.22516/25007440.813

Altmetric

Crossref Cited-by logo
Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views
QR Code

Some similar items: