Compromiso gastrointestinal por enfermedad de injerto contra huésped

Palabras clave: Enfermedad injerto contra Huésped, Sistema digestivo, Tracto gastrointestinal, Trasplante, Células Madre

Resumen

La enfermedad de injerto contra huésped es una complicación frecuente después del trasplante de células madre. El tracto digestivo se afecta en una gran proporción de los pacientes que la sufren, con consecuencias que pueden llegar a ser fatales. El abordaje adecuado, que incluye el uso de estudios endoscópicos, permite descartar diagnósticos diferenciales y brindar un manejo temprano de la enfermedad.

Descargas

La descarga de datos todavía no está disponible.

Biografía del autor/a

Alvaro Andres Gomez-Venegas, Hospital Pablo Tobón Uribe

Médico Internista y Gastroenterólogo. Medellín, Colombia.

Gabriel Mosquera-Klinger, Hospital Pablo Tobón Uribe

Médico Internista y Gastroenterólogo. Medellín, Colombia.

Jhon Jaime Carvajal Gutiérrez, Hospital Pablo Tobón Uribe

Médico Internista y Gastroenterólogo. Medellín, Colombia.

Fabián Juliao Baños, Hospital Pablo Tobón Uribe

Medico Internista y Gastroenterólogo. Medellín, Colombia.

Andrés Goldstein Rothstein , Hospital Pablo Tobón Uribe

Cirugía general y Endoscopia digestiva. Medellín, Colombia.

Juan Camilo Pérez Cadavid, Hospital Pablo Tobón Uribe

Médico Patólogo. Medellín, Colombia.

Juan Felipe Morantes Rubiano, Centro de Salud San José De Nimaima

Médico, Universidad de la Sabana. Médico rural, Centro de Salud San José De Nimaima. Nimaima, Cundinamarca, Colombia.

Referencias bibliográficas

Ramachandran V, Kolli SS, Strowd LC. Review of Graft-Versus-Host Disease. Dermatol Clin. 2019;37(4):569-82. https://doi.org/10.1016/j.det.2019.05.014

Jagasia M, Arora M, Flowers MED, Chao NJ, McCarthy PL, Cutler CS, et al. Risk factors for acute GVHD and survival after hematopoietic cell transplantation. Blood. 2012;119(1):296-307. https://doi.org/10.1182/blood-2011-06-364265

Ratanatharathorn V, Nash RA, Przepiorka D, Devine SM, Klein JL, Weisdorf D, et al. Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. Blood. 1998;92(7):2303-14.

Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report. Biol Blood Marrow Transplant. 2015;21(3):389-401.e1.

Endo K, Fujishima F, Kuroha M, Moroi R, Onodera M, Naito T, et al. Effective and less invasive diagnostic strategy for gastrointestinal GVHD. Endosc Int Open. 2018;06(03):E281-91. https://doi.org/10.1055/s-0043-122226

Naymagon S, Naymagon L, Wong SY, Ko HM, Renteria A, Levine J, et al. Acute graft-versus-host disease of the gut: Considerations for the gastroenterologist. Nat Rev Gastroenterol Hepatol. 2017;14(12):711-26. https://doi.org/10.1038/nrgastro.2017.126

Ferrara JLM, Chaudhry MS. GVHD: Biology matters. Blood Adv. 2018;2(22):3411-7. https://doi.org/10.1182/bloodadvances.2018020214

Saidu NEB, Bonini C, Dickinson A, Grce M, Inngjerdingen M, Koehl U, et al. New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions. Front Immunol. 2020 Oct 9;11:578314. https://doi.org/10.3389/fimmu.2020.578314

Jamil MO, Mineishi S. State-of-the-art acute and chronic GVHD treatment. Int J Hematol. 2015;101(5):452-66. https://doi.org/10.1007/s12185-015-1785-1

Socié G, Ritz J. Current issues in chronic graft-versus-host disease. Blood. 2014;124(3):374-84. https://doi.org/10.1182/blood-2014-01-514752

Rajan AV, Trieu H, Chu P, Lin J, Kidambi TD. Assessing the yield and safety of endoscopy in acute graft-vs-host disease after hematopoietic stem cell transplant. World J Gastrointest Endosc. 2020;12(10):341-54. https://doi.org/10.4253/wjge.v12.i10.341

Matsuda K, Ono S, Tanaka I, Inoue M, Kinowaki S, Ishikawa M, et al. Histological and magnified endoscopic evaluation of villous atrophy in gastrointestinal graft-versus-host disease. Ann Hematol. 2020;99(5):1121-8. https://doi.org/10.1007/s00277-020-03966-y

Kreisel W, Dahlberg M, Bertz H, Harder J, Potthoff K, Deibert P, et al. Endoscopic diagnosis of acute intestinal GVHD following allogeneic hematopoietic SCT: a retrospective analysis in 175 patients. Bone Marrow Transplant. 2012;47(3):430-8. https://doi.org/10.1038/bmt.2011.137

Velasco-Guardado A, López-Corral L, Alvarez-Delgado A, Flores-Corral T, Geijo-Martínez F, Caballero-Barrigón D, et al. Endoscopic evaluation and histological findings in graft-versus-host disease. Rev Espanola Enfermedades Dig Organo Of Soc Espanola Patol Dig. 2012;104(6):310-4. https://doi.org/10.4321/S1130-01082012000600005

Trifilio SM, Pi J, Mehta J. Changing epidemiology of Clostridium difficile-associated disease during stem cell transplantation. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2013;19(3):405-9. https://doi.org/10.1016/j.bbmt.2012.10.030

ASGE Standards of Practice Committee, Shen B, Khan K, Ikenberry SO, Anderson MA, Banerjee S, et al. The role of endoscopy in the management of patients with diarrhea. Gastrointest Endosc. 2010;71(6):887-92. https://doi.org/10.1016/j.gie.2009.11.025

ASGE Standards of Practice Committee, Sharaf RN, Shergill AK, Odze RD, Krinsky ML, Fukami N, et al. Endoscopic mucosal tissue sampling. Gastrointest Endosc. 2013;78(2):216-24. https://doi.org/10.1016/j.gie.2013.04.167

Morita K, Fujiwara S-I, Ikeda T, Kawaguchi S-I, Toda Y, Ito S, et al. Identification of endoscopic factors that predict poor responses to steroids in patients with gastrointestinal acute graft-versus-host disease. Bone Marrow Transplant. 2021;56(4):963-967. https://doi.org/10.1038/s41409-020-01096-7

Bhutani D, Dyson G, Manasa R, Deol A, Ratanatharathorn V, Ayash L, et al. Incidence, risk factors, and outcome of cytomegalovirus viremia and gastroenteritis in patients with gastrointestinal graft-versus-host disease. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2015;21(1):159-64. https://doi.org/10.1016/j.bbmt.2014.10.004

Malard F, Mohty M. New insight for the diagnosis of gastrointestinal acute graft-versus-host disease. Mediators Inflamm. 2014;2014:701013. https://doi.org/10.1155/2014/701013

Coron E, Laurent V, Malard F, Le Rhun M, Chevallier P, Guillaume T, et al. Early detection of acute graft-versus-host disease by wireless capsule endoscopy and probe-based confocal laser endomicroscopy: results of a pilot study. United Eur Gastroenterol J. 2014;2(3):206-15. https://doi.org/10.1177/2050640614529283

Blanco-Velasco G, Palos-Cuellar R, Domínguez-García MR, Solórzano-Pineda OM, Zamarripa-Mottú RA, Martínez-Camacho C, et al. Utility of capsule endoscopy in the diagnosis of gastrointestinal graft-versus-host disease. Rev Gastroenterol Mex. 2021;86(3):215-219. https://doi.org/10.1055/s-0040-1704848

Bertz H, Afting M, Kreisel W, Duffner U, Greinwald R, Finke J. Feasibility and response to budesonide as topical corticosteroid therapy for acute intestinal GVHD. Bone Marrow Transplant. 1999;24(11):1185-9. https://doi.org/10.1038/sj.bmt.1702055

MacMillan ML, Robin M, Harris AC, DeFor TE, Martin PJ, Alousi A, et al. A refined risk score for acute graft-versus-host disease that predicts response to initial therapy, survival, and transplant-related mortality. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2015;21(4):761-7. https://doi.org/10.1016/j.bbmt.2015.01.001

Ippoliti C, Champlin R, Bugazia N, Przepiorka D, Neumann J, Giralt S, et al. Use of octreotide in the symptomatic management of diarrhea induced by graft-versus-host disease in patients with hematologic malignancies. J Clin Oncol Off J Am Soc Clin Oncol. 1997;15(11):3350-4. https://doi.org/10.1200/JCO.1997.15.11.3350

Akpek G, Valladares JL, Lee L, Margolis J, Vogelsang GB. Pancreatic insufficiency in patients with chronic graft-versus-host disease. Bone Marrow Transplant. 2001;27(2):163-6. https://doi.org/10.1038/sj.bmt.1702769

Figura 1. Compromiso por EICH en mucosa duodenal
Publicado
2022-05-31
Cómo citar
Gomez-Venegas, A. A., Mosquera-Klinger, G., Carvajal Gutiérrez, J. J., Juliao Baños, F., Goldstein Rothstein , A., Pérez Cadavid, J. C., & Morantes Rubiano, J. F. (2022). Compromiso gastrointestinal por enfermedad de injerto contra huésped. Revista Colombiana De Gastroenterología, 37(2), 225-232. https://doi.org/10.22516/25007440.771
Sección
Reporte de Casos
Crossref Cited-by logo

Más sobre este tema

Artículos más leídos del mismo autor/a