Colestasis en el adulto: enfoque diagnóstico y terapéutico. Revisión de tema

  • Andres Jose Gómez Aldana Fundación Santa Fe de Bogotá- Universidad de los Andes http://orcid.org/0000-0002-7954-4910
  • Mónica Tapias Fundación Santa Fé de Bogotá
  • Adán Jose Lúquez Mindiola Gut Médica
Palabras clave: Colestasis, intrahepática, extrahepática

Resumen

La colestasis es uno de los motivos de consulta más frecuentes en hepatología. Se genera por una alteración en la síntesis, la secreción o el flujo de la bilis, a través del tracto biliar. Esta se define por una elevación de enzimas como la fosfatasa alcalina (Alkaline Phosphatase, ALP) y la gamma-glutamil transferasa, y en estadios tardíos con la hiperbilirrubinemia, al igual que con otras manifestaciones clínicas, tales como el prurito y la ictericia.

El enfoque diagnóstico implica establecer el origen de dicha elevación, determinando si es intrahepática o extrahepática. Si es intrahepática, se debe esclarecer si proviene de los hepatocitos o de la vía biliar de pequeño y de gran calibre. El tratamiento dependerá de la etiología, por lo cual es importante un diagnóstico preciso. En esta revisión se presenta la fisiopatología y un enfoque diagnóstico y terapéutico.

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Biografía del autor/a

Mónica Tapias , Fundación Santa Fé de Bogotá

Médica internista, hepatóloga

Citas

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Mecanismos principales de la colestasis
Publicado
2020-03-27
Cómo citar
Gómez Aldana, A. J., Tapias , M., & Lúquez Mindiola, A. J. (2020). Colestasis en el adulto: enfoque diagnóstico y terapéutico. Revisión de tema. Revista Colombiana De Gastroenterología, 35(1), 76-86. https://doi.org/10.22516/25007440.375
Sección
Revisión de tema